Annie Alexander was born in Mecklenberg County, NC in 1864 and graduated from Woman's Medical College in Philadelphia in 1884. She returned to North Carolina in 1887 as the first woman to practice medicine in the South. The collection includes letters she wrote to her father, Dr. John Brevard Alexander, while a student and intern at the Women's Medical College in Philadelphia (1884-85); patient records; financial accounts; essays on medical topics; and newspaper clippings.

Papers of a Mecklenburg County physician. Includes account books, medical journals, correspondence, memorabilia, and writings. Also documents his services as a surgeon in the 37th North Carolina Regiment of the Confederate Army, as well as his general interest in the Civil War.